INVESTIGADORES
KORNBLIHTT Alberto Rodolfo
artículos
Título:
Inhibition of cyclic 3',5' monophosphate synthesis in rat testis by L-triiodothyronine.
Autor/es:
FLAWIƁ, M. M; KORNBLIHTT AR; DE MENDOZA D; TORRES H N
Revista:
MOLECULAR AND CELLULAR BIOCHEMISTRY
Editorial:
SPRINGER
Referencias:
Año: 1981 p. 185 - 185
ISSN:
0300-8177
Resumen:
Cytosolic adenylate cyclase activity from rat seminiferous tubules is inhibited by L-triiodothyronine (L-T3). In a typical dose-response curve, using Mn-ATP as substrate, no effect is observed at 10(-10) M L-T3; about 15 to 25% inhibition is found in the range between 10(-9) and 10(-6) M L-T3 and finally a sharp enzyme inhibition is evident at increasing hormone concentrations from 10(-6) to 10(-4) M. Incubation of decapsulated testes with L-T3 leads to a decrease of intracellular cyclic AMP levels. Dose-response relationships for such effect are similar to those found for adenylate cyclase activity. In this case a clear response is observed at 10(-8) M L-T3.
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