INVESTIGADORES
KORNBLIHTT Alberto Rodolfo
artículos
Título:
Epigenetics in alternative pre-mRNA splicing
Autor/es:
LUCO, R.; ALLĂ“, M.; SCHOR, I.; KORNBLIHTT, A. R.; MISTELI, T.
Revista:
CELL
Editorial:
CELL PRESS
Referencias:
Lugar: United States; Año: 2011 vol. 144 p. 16 - 16
ISSN:
0092-8674
Resumen:
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.