INVESTIGADORES
KORNBLIHTT Alberto Rodolfo
artículos
Título:
Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
Autor/es:
SCHOR IGNACIO; KORNBLIHTT, ALBERTO R
Revista:
Communicative and Integrative Biology
Editorial:
Landes Biosciences
Referencias:
Año: 2009 vol. 2 p. 341 - 341
ISSN:
1942-0889
Resumen:
Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in order to regulate alternative splicing of the neural cell adhesion molecule (NCAM) mRNA. This example illustrates how an extracellular stimulus can influence transcription-coupled alternative splicing, strengthening the link between chromatin structure, transcriptional elongation and mRNA processing.
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