Gene expression and ChIP-seq data analyses confirm FOXM1 as a player in prostate cancer biology.

BRANDANI JAVIER; BIZZOTO, JUAN; ABBATE MERCEDES; LEONARDI DAIANA; GUERON GERALDINE; VAZQUEZ ELBA; COTIGNOLA JAVIER

Mar del Plata

Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica 2019; 2019

SAIC

Dysregulation of the androgen receptor (AR) and glucocorticoid receptor (GR) expressionis responsible, at least in part, for the development and progression of prostate cancer(PCa). GR might also have oncogenic or tumor suppressor activities depending on thepresence/absence of AR and other regulatory cofactors such as the Forkhead Box (FOX).We previously showed the involvement of FOXM1 in cell migration, proliferation, viability,morphology, apoptosis, and the modulation of the transcriptional activity of GR and AR inPCa cells. The aim of this study was to validate the potential use of FOXM1 as abiomarker for PCa and understand the molecular mechanisms involved. We tookadvantage of public repositories to study the association between FOXM1 expression andthe clinico-pathological characteristics of patients with PCa. We downloaded rawtranscriptome data from 3 datasets GSE54460, GSE94767 and PRAD-TCGA. Theexpression of FOXM1 and AR were positively correlated with Gleason score (p