INVESTIGADORES
VAZQUEZ Elba Susana
artículos
Título:
Altered Signaling Pathways in Prostate Cancer Drive Metabolic Fate. *International
Autor/es:
ANTICO ARCIUCH, VALERIA GABRIELA; VAZQUEZ, ELBA SUSANA; GUERON, GERALDINE; COTIGNOLA, JAVIER HERNÁN
Revista:
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
Editorial:
WORLD WIDE JOURNALS
Referencias:
Lugar: Gujarat; Año: 2017 vol. 6 p. 614 - 619
ISSN:
2277-8179
Resumen:
Prostate cancer is one of the leading causes of men death worldwide.Several signaling pathways are highly implicated in the progression of thisdisease. Interestingly, variations in a single gene can orchestrate changesin a metabolic pathway and thus, confer an adaptive advantage. Metabolicreprogramming has emerged as one of the hallmarks of cancer and arises asconsequence of changes in critical signaling pathways provoked bybalance disruption between oncogenes and tumor suppressors expression.Therefore, metabolomic analyses provide relevant information that isnot available with only genomic or proteomic studies. Noticeably, basalenergetic status in luminal epithelial cells of the prostate gland contrastswith other tissues since Krebs cycle is altered so as to generate highcitrate levels achieving a more glycolytic phenotype. Furthermore, thealteredsignaling pathways in prostate cancer depict changes in cellular metabolismthat support the demands of rapid cell division. Particularly, metabolicpathways significantly altered in this malignancy are glutaminolysis andlipid metabolism that contribute directly to the production of acetyl-CoAand NADPH required for the synthesis of fatty acids. Therefore, decipheringthe metabolic rewiring propelled by signaling pathways dysregulationis vital for the development of new therapeutic approaches in prostatecancer. Advances in these fields highlight the importance of changes inenergetic metabolism during the progression to castration resistantprostate cancer and bone metastases.