INVESTIGADORES
ZENI Susana Noemi
congresos y reuniones científicas
Título:
Histomorphometrical comparison of three different bone grafts: deproteinized bovine bone, bioglass and, synthetic hydroxyapatite
Autor/es:
PELLEGRINI MIGUEL; GONZALEZ CHAVES M; ORZUZA R,; ZENI S; PELLEGIRNI G,
Reunión:
Congreso; 45th European Calcified Tissue Society Congress (ECTS-2018).; 2018
Resumen:
Bone graft implantation is required to guide bone repair. Deproteinizedbovine bone putty (BB), bioglass (BG) and, synthetichydroxyapatite (SH) are frequently indicated as bone grafting materialsdue to their osteoconductive properties. We compared the bonehealing response of BB, BG and SH (Synergy, Odontit ImplantSystems, Argentina) in a critical sized bone defect. We created a bonedefect of 4 mm diameter in rat tibiae for implantation with eachbiomaterial (N = 30 rats). Samples were collected at 2 and 4 weeksfor histological and histomorphometrical analysis of new bone formation(NBF) and remaining particles of each device (RP).Results: Percentage of NBF (mean ± SD): 2 weeks: Controlgroup: 6.60 ± 3.71; BB group: 23.23 ± 3.89*; BG group:18.35 ± 5.23*; SH group: 26.27 ± 9.30*; 4 weeks: Control group:6.69 ± 2.38; BB group: 24.37 ± 3.66*; BG group: 17.45 ± 6.64*;SH group: 32.25 ± 3.80*. Percentage of RP: 2 weeks: Control group:0 ± 0; BB group: 5.04 ± 1.39*; BG group: 3.03 ± 2.31*; SH group:4.46 ± 2.87*; 4 weeks: Control group: 0 ± 0; BB group:4.45 ± 2.35*; BG group: 2.87 ± 1.14*; SH group: 3.78 ± 1.68*(*p�.05 vs. control group; p = NS between BB, BG and SHgroups). Although SH exhibited a trend towards increased NBF wedid not find statistical significance among the three biomaterials. Bonehealing at the implanted sites, was accompanied by a progressiveinflammatory response consistent with the expected histologicalstages of bone repairing. All biomaterials were associated with trabecularbone formation. To date, there are no studies comparing theeffect of these biomaterials in bone healing. While further studiesneed to be done, our results indicate that BB, BG and SH exhibitsimilar characteristics in terms of osteoconduction. Furthermore, thethree biomaterials were histologically substantially equivalent.Keywords: Bone healing; biomaterials; critical sized bone defect;bovine bone; bioglass; synthetic hydroxyapatite