Evaluation of a new bovine biomaterial to induce mandibular bone healing in dental procedures.

PELLEGIRNI G,; GONZALES-CHAVES M,; DURAN F,; ORZUZA R,; PARODI L; ZENI S N

Buenos Aires

Congreso; Reuncion Conjunta de Biociencias; 2017

SAIC- SAI-SAFE-SAIB

Bovine bone grafts are biocompatibile, osteoconductive, generate new bone apposition and prevent resorption. Synergy Bone Matrix (SBM) [Odontit Implant System, Argentina] effect was evaluated and compared with a recognized commercial material Bio-Oss (BO) [Geistlich, Switzerland] in rabbits. Bone healing process was evaluated by creating a critical sized bone defect (CSBD) at both sides of mandibles filling with each biomaterial or remaining unfilled (C: control). Determinations: clinical daily, systemic toxicity (usPCR and leukocytes) every 4 days, lungs, kidney and liver pathology, bone formation and device resorption evaluation; X-rays and compression and flexural biomechanical tests at sacrifice (4, 8 and 12 weeks). No systemic toxicity signs, fibrosis or adipose tissue development was observed. New bone formation, remaining bone substitute and mandibular radio-opacity were similar in BO and SBM. C presented significantly lower values (*p