INVESTIGADORES
ZENI Susana Noemi
congresos y reuniones científicas
Título:
DIETARY CALCIUM CONTENT INFLUENCES BODY COMPOSITION AND BONE MARKERS OF OBESE (BETA O) GROWING RATS C.
Autor/es:
MAROTE C; WEISSTAUB A; HERNANDEZ E; PELLEGRINI G; PORTELA ML; GONZALES CHAVES M; ZENI S
Lugar:
Glasgow
Reunión:
Congreso; 37º EUROPEAN CALCIFIED TISSUE INTERNATIONAL MEETING; 2010
Institución organizadora:
EUROPEAN CALCIFIED TISSUE INTERNATIONAL
Resumen:
effect of feeding different dietary calcium (Ca) levels on body weight (BW) and composition and its relationship to bonemetabolism, in genetically modified obese (?À) rats during growth . Rats were mated and fed diets varying Ca content:high: 0.9% (?ÀH); normal: 0.5% (?ÀN); low: 0.2% (?ÀL). A Wistar group was run simultaneously (W) as control and fed a dietaccording to AIN?L93. At weanling, the male pups continued feeding the same diet till 50 days of age. At the end of theexperience, body composition, bone alkaline phosphatase (BAP), BGP and CTX (ELISA) were evaluated. Results(mean?}SD): Food intake was similar in all groups. BW was lower in ?ÀH vs. ?ÀN and ?ÀH groups (162?}18 vs. 217?}31221?}37g; p<0.01). In ?À groups ashes content (g/100g) increased as dietary Ca content increases (1.88?}0.26; 2.42?}0.24,2.51?}0.21; p<0.03) without reaching W values (2.71?}0.21). Lipids% was higher in ?ÀL and ?ÀN (14.7?}1.3 and 13.6?}2.7) vs.W (10.9?}2.6) and ?ÀH (12.6?}2.2) (p<0.05). BAP (IU/L) did not show differences among ?À groups (186?}27, 193?}39 and184?}30), being higher vs. W (67.8?}10.0). BGP (ug/ml) exhibit an inverse correlation with dietary Ca level in ?À (447?}45,375?}46 and 279?}73), being lower than W (825?}106) (p<0.01). CTX (mg/ml) did not show differences between W (88?}16)and ?ÀH (87?}4) which were higher vs ?ÀN and ?ÀL (69?}12 and 70?}3, respectively) (p<0.01). Conclusions: The increasein dietary Ca content seems to decrease BW and body lipids content and to increase mineral content of ?À rats. Thesefindings together with changes in bone markers suggest an imbalance in bone metabolism related to adipose tissue. Thisabstract is part of C. Marote PhD. UBACyT B 091.