Lipid Profile and total bone mineral content in an experimental model of nutritional hypercholesterolemia.

MACRI V; ZAGO V; ZENI S; RODRIGUEZ P; GAMBA A; SCHREIER L; FRIEDMAN S

San Diego, California. USA:

Congreso; Faseb 2008; 2008

FASEB

Studies showed a strong relationship between fat diets and CVD but not, cholesterol levels involving bone health. Objective: to investigate in an experimental model of nutritional hypercholesterolemia, the association between lipid profile and total bone mineral content (BMC) under high-oleic-acid sunflower oil (HOSO) and sunflower oil (SO) diets. Weaning male Wistar rats (n=56) were randomly assigned to one of 7 groups: a) control group (C) or b) six experimental (E 1-6) for 6 wk. C received rodent diet for 6 wk. E were fed a high cholesterol diet (HCD) (pellets+biliary salts+colesterin+butter) for 3 wk (stage 1) and then (stage 2):  E1, E3, E6 replaced the HCD by HOSO, SO or pellets, respectively. E2, E4: replaced butter by HOSO or SO, respectively. E5 was kept on HCD. After 6 wk, blood was drawn for cholesterol (CHO, mg/dl), Triglycerides (TG, mg/dl), high density lipoprotein-cholesterol (HDL-CHO), HDL-non-cholesterol (N-HDL-CHO) & N-HDL/HDL ratios. BMC by DXA (Lunar DPX-L) was measured. Pearson´s correlation coefficients were calculated, p was set at 5%. Results: the correlation between lipid profile vs. BMC were: +0.18 (ns), -0.65 (p<0.0001), -0.66 (p<0.0001), +0.32 (p<0.01) and -0.65 (p<0.0001) for TG, CHO, N-HDL, HDL-CHO and N-HDL/HDL, respectively. Conclusion: there is a strong relationship between atherogenic lipid profile and bone formation.