Hypercholesterolemia and bone metabolism

MACRI EV; ZAGO, V; SCHREIER L; RODRIGUEZ P; ZENI SN; FRIEDMAN S

Buenos Aires

Congreso; XXIV Reunión de la Asociación Argentina de Osteología y Metabolismo Mineral.; 2007

AAOOM

Consumption of high-oleic sunflower oil (h-ù9) has been recommended in adults undergoing hypercholesterolemia. However, questions of the effect of these diets on bone metabolism in infancy are faced by physicians. Objective: To study the effects of dietary h-ù9 in growing rats with a nutritional hypercholesterolemia. At weaning, 24 male Wistar rats, randomly assigned to 1 of 3 different groups: control (C) fed with high-cholesterol diet (HCD = pellets, cholesterol, biliary salts and butter) and two experimental groups h-ù9 or ù6 (diets prepared replacing butter by h-ù9 or regular sunflower oil (ù6)). They were fed ?ad libitum? for 6 weeks. In the entire period, C was given HCD; but h-ù9 and ù6 received the HCD diet for 3 weeks and then h-ù9 or ù6 diet up to 6 weeks. Rats´ body weight (wt) and diet intake (kcal/100 g rat BW) were recorded twice a week. At 3 and 6 weeks, blood was drawn for serum lipid profile. At 6 weeks, BMD and BMC/wt (DXA Lunar DPX) were performed. Results (mean ± SD): C, h-ù9 and ù6 showed at 3 weeks, serum cholesterol (COL) = 287.0 ± 89.1, 203.9 ± 28.3, and 234.3 ± 47.9 mg/dl (p = 0.069), respectively. At 6 weeks, COL = 231.4 ± 35.7, 314.8 ± 32.5, and 189.4 ± 22.9 mg/dl, respectively (p < 0.0001) and BMC/wt = 8.7 ± 0.8, 7.0 ± 0.8, and 8.9 ± 0.8 (p = 0.0006), respectively. BW, diet intake, triglyceride level and BMD (6 weeks) were similar (p > 0.05). In h-ù9, serum COL and BMC/Wt were higher and lower, respectively, as compared to the other groups. Based on these controversial results, replacing saturated fat by h-ù9 warrants further studies. This is of importance in the management of patients at risk as well as in food industry. Grant from UBACyT O 004.