Diets high in monounsaturated fatty acids reduce bone mass

GONZALES-CHAVES M,; ALSINA E; MACRI E; SUAREZ C; LANATA E; RODRIGUEZ P; ZENI S

Athenas

Congreso; 38th. European Calcified Tissue Simposium (ECTS).; 2011

DIETS HIGH IN MONOUNSATURATED FATTY ACIDS REDUCE BONE MASS? M. M. Gonzales Chaves 1,*, E. Alsina 1, E. Macri 1, C. Suarez 1, E. Lanata 2, P. Rodriguez 1, S. Zeni 1, S. Friedman 1 1Biochemistry, 2Operative Dentistry, UNIVERSITY OF BUENOS AIRES, Buenos Aires, Argentina Abstract: Diets rich in MUFA are indicated for the treatment of nutritional hypercholesterolemia (NHC); however, new sources as high oleic sunflower oil (HOSO, rich in n-9) from sunflower oil have not been adequately studied.Objective: to study in growing healthy rats or with NHC, the effect of diets rich in HOSO on body growth, cardio protective parameters (total cholesterol (T-C) triglyceride (TG), HDL-C and noHDL-C), % liver weight/body weight (% LW/BW), % body fat (% BF) and visceral fat % (% VF). Total skeleton bone mineral density (BMD) and content (BMC).Weaning male Wistar rats (n = 24) were randomly assigned to one of three groups. For 8 wks, a control group (CO) received an AIN-93G diet, while another group, a diet rich in HOSO (HOSO). The remained group received for 3 wks a diet rich in saturated fat (SF) and C. Then, for 5 wks (T8) SF was replaced by HOSO (HOSO-C).At T3, serum T-C (mg/dL) and T8, serum T-C (mg/dL), TG (mg/dL), HDL-C (mg/dL) and noHDL-C (mg/dL) were determined. BMD (g/cm2) and BMC (g) (DXA, Lunar DPX), % LW/BW, %BF, %VF were assayed. Weekly, body size expressed as BW (BWV, g%) and length (BLV, cm/10cm) velocities and food consumption (g/BW 0.75/d) were recorded. Results (mean ± SD, ANOVA, SNK a posteriori, 5% significance level). At T3, HOSO-C group showed HC (p