The severe osteopenia induce by ovariectomy and a low protein intake was reduced by olpadronate treatment.

GONZALES CHAVES MMS, ; MARROTE C, ; MANDALUNIS P, ; FRIEDMAN SM, ; ZENI SN.

Viena

Congreso; 36th European Calcified Tissue Symposium; 2009

ECTS

Background: The association of low bone mineral density (BMD) with angiographically determined coronary atherosclerosis in men is unclear. Methods: We enrolled 623 consecutive men undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). BMD was assessed by dual X-ray absorptiometry. CAD was diagnosed in the presence of any coronary artery lumen narrowing at angiography, and coronary stenoses with lumen narrowing >=50% were considered significant. Results: From the total study cohort (mean age of 64±11 years), 207 patients (33.2%) had osteopenia and 65 (10.4%) had osteoporosis; at angiography, CAD was diagnosed in 558 patients (89.6%) and 403 (64.7%) had significant coronary stenoses. In multivariate logistic regression, neither osteopenia nor osteoporosis was associated with CAD (adjusted odds ratios (ORs)=0.71 [95% confidence interval, 0.40–1.23], p=0.222 and 1.03 [0.38–2.80]; p=0.955, respectively) nor with significant coronary stenoses (OR=0.74 [0.52–1.07],–1.23], p=0.222 and 1.03 [0.38–2.80]; p=0.955, respectively) nor with significant coronary stenoses (OR=0.74 [0.52–1.07],–1.07], p=0.112 and 0.72 [0.41–1.26]; p=0.251, respectively). Conclusions: The prevalence of low BMD is high in men undergoing coronary angiography; however, low BMD is not associated with angiographically determined coronary atherosclerosis in men.=0.112 and 0.72 [0.41–1.26]; p=0.251, respectively). Conclusions: The prevalence of low BMD is high in men undergoing coronary angiography; however, low BMD is not associated with angiographically determined coronary atherosclerosis in men. Conflict of interest: None declared.None declared.