Does a new source of monounsaturated fatty acids improve lipid profile and body mineral content in nutritional hypercholesterolemia?

MACRI V; JUIZ N; RAMOS C, . ; GONZALES CHAVES MMS, ; GAMBA C, ; ZAGO V, ; SCHERIER L,; RODRIGUEZ P, ; ZENI S, ; FRIEDMAN S

Buenos Aires

Congreso; XXVI Reunión Anual de la AAOMM.; 2009

AAOMM

Does a new source of monounsaturated fatty acids improve lipid profile and body mineral content in nutritional hypercholesterolemia? E.V. Macri, N. Juiz, C. Ramos, M.M. Gonzales Chaves, C. Gamba, V. Zago, L. Scherier, P. Rodriguez, S. Zeni, S. Friedman Biochemistry Department School of Dentistry, Department Clinic Biochemistry School Pharmacy Buenos Aires University In recent years, food industries has demonstrated increased interest in food rich in high-oleic-acid sunflower oil (HOSO, ù9) made from sunflower oil (SO, ù6) to substitute trans-fatty acids. Diets containing HOSO are often promoted to treat nutritional hypercholesterolemia (NHC); however, there are limited data about the effect of this new source of monounsaturated fatty acids (MUFA; HOSO, ù9) on lipid profile and body mineral content (BMC). We performed the study in an experimental model of NH. Weaning male Wistar rats (n=34) were randomly assigned to one of 5 groups (C, Control; E, Experimental). All groups underwent an atherogenic diet (AD, pellets+saturated fat+cholesterin) for 3 weeks (T3), followed by 3 weeks (T6) of the following: C remained on AD; E1 and E2 replaced AD by HOSO and SO, respectively; E3 and E4 replaced saturated fat by HOSO and SO, respectively. At T3 serum total CHO (TCHO) and at T6, TCHO, triglycerides, TBARS, HDL-CHO, n-HDL-CHO, and BMC were evaluated by DEXA (Lunar DPX-L). Results (median± SD, Pearson's correlation coefficients were calculated; p=0.05). At T3, all groups showed HC (p<0.001). At T6, E3 increased in TCHO and TBARS vs. E2 and C (p<0.001). n-HDL-CHO decreased in rats fed UFA (p<0.001). The correlation coefficients between lipid profile and BMC for TCHO, n-HDL-CHO, and HDL-CHOwere as follows: HC rats (n=20),ù9) made from sunflower oil (SO, ù6) to substitute trans-fatty acids. Diets containing HOSO are often promoted to treat nutritional hypercholesterolemia (NHC); however, there are limited data about the effect of this new source of monounsaturated fatty acids (MUFA; HOSO, ù9) on lipid profile and body mineral content (BMC). We performed the study in an experimental model of NH. Weaning male Wistar rats (n=34) were randomly assigned to one of 5 groups (C, Control; E, Experimental). All groups underwent an atherogenic diet (AD, pellets+saturated fat+cholesterin) for 3 weeks (T3), followed by 3 weeks (T6) of the following: C remained on AD; E1 and E2 replaced AD by HOSO and SO, respectively; E3 and E4 replaced saturated fat by HOSO and SO, respectively. At T3 serum total CHO (TCHO) and at T6, TCHO, triglycerides, TBARS, HDL-CHO, n-HDL-CHO, and BMC were evaluated by DEXA (Lunar DPX-L). Results (median± SD, Pearson's correlation coefficients were calculated; p=0.05). At T3, all groups showed HC (p<0.001). At T6, E3 increased in TCHO and TBARS vs. E2 and C (p<0.001). n-HDL-CHO decreased in rats fed UFA (p<0.001). The correlation coefficients between lipid profile and BMC for TCHO, n-HDL-CHO, and HDL-CHOwere as follows: HC rats (n=20),ù6) to substitute trans-fatty acids. Diets containing HOSO are often promoted to treat nutritional hypercholesterolemia (NHC); however, there are limited data about the effect of this new source of monounsaturated fatty acids (MUFA; HOSO, ù9) on lipid profile and body mineral content (BMC). We performed the study in an experimental model of NH. Weaning male Wistar rats (n=34) were randomly assigned to one of 5 groups (C, Control; E, Experimental). All groups underwent an atherogenic diet (AD, pellets+saturated fat+cholesterin) for 3 weeks (T3), followed by 3 weeks (T6) of the following: C remained on AD; E1 and E2 replaced AD by HOSO and SO, respectively; E3 and E4 replaced saturated fat by HOSO and SO, respectively. At T3 serum total CHO (TCHO) and at T6, TCHO, triglycerides, TBARS, HDL-CHO, n-HDL-CHO, and BMC were evaluated by DEXA (Lunar DPX-L). Results (median± SD, Pearson's correlation coefficients were calculated; p=0.05). At T3, all groups showed HC (p<0.001). At T6, E3 increased in TCHO and TBARS vs. E2 and C (p<0.001). n-HDL-CHO decreased in rats fed UFA (p<0.001). The correlation coefficients between lipid profile and BMC for TCHO, n-HDL-CHO, and HDL-CHOwere as follows: HC rats (n=20),ù9) on lipid profile and body mineral content (BMC). We performed the study in an experimental model of NH. Weaning male Wistar rats (n=34) were randomly assigned to one of 5 groups (C, Control; E, Experimental). All groups underwent an atherogenic diet (AD, pellets+saturated fat+cholesterin) for 3 weeks (T3), followed by 3 weeks (T6) of the following: C remained on AD; E1 and E2 replaced AD by HOSO and SO, respectively; E3 and E4 replaced saturated fat by HOSO and SO, respectively. At T3 serum total CHO (TCHO) and at T6, TCHO, triglycerides, TBARS, HDL-CHO, n-HDL-CHO, and BMC were evaluated by DEXA (Lunar DPX-L). Results (median± SD, Pearson's correlation coefficients were calculated; p=0.05). At T3, all groups showed HC (p<0.001). At T6, E3 increased in TCHO and TBARS vs. E2 and C (p<0.001). n-HDL-CHO decreased in rats fed UFA (p<0.001). The correlation coefficients between lipid profile and BMC for TCHO, n-HDL-CHO, and HDL-CHOwere as follows: HC rats (n=20),n=34) were randomly assigned to one of 5 groups (C, Control; E, Experimental). All groups underwent an atherogenic diet (AD, pellets+saturated fat+cholesterin) for 3 weeks (T3), followed by 3 weeks (T6) of the following: C remained on AD; E1 and E2 replaced AD by HOSO and SO, respectively; E3 and E4 replaced saturated fat by HOSO and SO, respectively. At T3 serum total CHO (TCHO) and at T6, TCHO, triglycerides, TBARS, HDL-CHO, n-HDL-CHO, and BMC were evaluated by DEXA (Lunar DPX-L). Results (median± SD, Pearson's correlation coefficients were calculated; p=0.05). At T3, all groups showed HC (p<0.001). At T6, E3 increased in TCHO and TBARS vs. E2 and C (p<0.001). n-HDL-CHO decreased in rats fed UFA (p<0.001). The correlation coefficients between lipid profile and BMC for TCHO, n-HDL-CHO, and HDL-CHOwere as follows: HC rats (n=20),n=20), −0.78 (0.0001),−0.78 (0.0001),+0.44 (0.06) vs. normorats (n=14), 0.03 (ns),−0.60 (0.02),+0.48 (0.08).No correlationwith triglycerides was found. The findings suggest that NHC individuals may not benefit from eating diets rich in HOSO. Efforts are needed to improve diets.We suggest to follow-up BMC. UBACyT O008 and O015. doi:10.1016/j.bone.2009.08.0380.78 (0.0001),−0.78 (0.0001),+0.44 (0.06) vs. normorats (n=14), 0.03 (ns),−0.60 (0.02),+0.48 (0.08).No correlationwith triglycerides was found. The findings suggest that NHC individuals may not benefit from eating diets rich in HOSO. Efforts are needed to improve diets.We suggest to follow-up BMC. UBACyT O008 and O015. doi:10.1016/j.bone.2009.08.038−0.60 (0.02),+0.48 (0.08).No correlationwith triglycerides was found. The findings suggest that NHC individuals may not benefit from eating diets rich in HOSO. Efforts are needed to improve diets.We suggest to follow-up BMC. UBACyT O008 and O015. doi:10.1016/j.bone.2009.08.03810.1016/j.bone.2009.08.038 Late onset of X-linked hypophosphatemic osteomala