INVESTIGADORES
ZENI Susana Noemi
congresos y reuniones científicas
Título:
End of winter versus end of summer levels of vitamin D, parathyroid hormone (PTH) and bone remodeling markers of women from Comodoro Rivadavia
Autor/es:
GONZALES CHAVES MACARENA MS; PONCE GRACIELA; FAJARDO MARIA A; PELLEGRINI GRETEL G; OLIVERI BEATRIZ; SOMOZA JULIA; LEONHARDT L; ZENI SUSANA N
Lugar:
Buenos Aires
Reunión:
Congreso; XXII Reunion Anual de Asociacion Argentina de Osteologia y Metabolismo Mineral; 2005
Institución organizadora:
Asociación Argentina de Osteologia y Metabolismo Mineral
Resumen:
Although it is frequent in elderly people, young adults may also be at risk of having inadequate vitamin D status. 25hydroxyvitamin D (25HOD) was evaluated in winter and summer to observe whether changes in vitamin D status have an effect on PTH and bone markers. Healthy women (45°S) (10 pre and 10 postmenopausal) were studied in March and August. In fasting blood 25HOD (ng/ml) (Diasorin), PTHmm (pg/ml), bone alkaline phosphatase (b-ALP: UI/L), collagen type I N-terminal propeptide (P1NP: ng/ml) and ?-CTX (ng/L) (Elecsys) and in urine CTX (ìg/mmol creatinine) (Crosslaps, Osteometer Bio Tech) were evaluated. Mean ± SD winter and summer values of pre and postmenopausal women respectively were: 25HOD: 14.7 ± 5.6, 26.5 ± 10.6*, 12.4 ± 4.0, 25.4 ± 10.0*; PTH: 46.0 ± 9.0, 26.5 ± 7.0*, 46.3 ± 10.6, 35.2 ± 15.0; b-ALP: 56 ± 11, 63 ± 10, 63 ± 17, 78 ± 17#, P1NP: 55.0 ± 12.1, 46.2 ± 10.6, 59.4 ± 16.6, 63.6 ± 20.7#-CTX: 210.2 ± 49.9, 213.2 ± 89.5, 213.2 ± 89.5, 356.6 ± 156.5#; urinary CTX: 188.9 ± 65.6, 146.1 ± 48.7, 234.9 ± 110.7, 232.4 ± 98.5#. (*) P < 0.05: summer vs. winter within the same group, (#) P < 0.05: pre vs. postmenopausal in the same season. Both groups had vitamin D insufficiency in winter and only premenopausal women presented a significant increment in PTH, without an increase in bone markers. Although 25HOD increased approximately 95% in summer, their vitamin D status was still deficient. Only bone markers were significantly different between pre- and postmenopausal summer values. Conclusion: vitamin D insufficiency in winter was still deficient in summer. Grant from Bs Aires University M033.