INVESTIGADORES
ZENI Susana Noemi
congresos y reuniones científicas
Título:
Fat diet and bone maturation.
Autor/es:
SUAREZ CRISTINA; FERREIRA MONTEIRO ANDREA; RODRIGUEZ PATRICIA; ZENI SUSANA N; FRIEDMAN SILVIA M
Lugar:
Buenos Aires
Reunión:
Congreso; XXII Reunion Anual de la Asociacion Argentina de Osteologia y Metabolismo Mineral; 2005
Institución organizadora:
Asociación Argentina de OSteologia y Metabolismo Mineral
Resumen:
Serum leptin levels are positively correlationed with the percentage of body fat and is recognized as an indicator of energy intake. On the other hand, IGF I can be considered as a signal linking between calories available, fat storage and proteins. The purpose of this work was to determine leptin and IGF I serum levels at a peak of greaty growing (aged = 35 days) consuming diet restricted in 50% of the calories from lipids. Twenty-eight female weanling Wistar rats were randomly assigned one of the two diets provided a carbohydrate to fat ratio of 1:1 (control) or 3:1 with an E% (kcal of fat/ 100 kcal) of 36% (1:1) or 18% (3:1). At day 35, the animals were sacrificed (T = 35). Body weight (g) and length (cm) were measured and body composition (percentage of body fat by chemical method AOAC and bone mineral content by DXA Lunar DPX, BMC g) was determined. In five of them serum IGF I and leptin levels were measured (ELISA, ng/ml). 50% restriction produced: significant decrease in the percentage of body fat, bone mineral content and serum leptin level. While body length remained no significant different, serum IGF I levels evidenced a clear tendency to diminished. Our results suggest that IGF I and leptin may be highly involved in the accurate development of the bone tissue.