Defining the Pattern of the Arousal-Related Motor-Behavioral Episodes (AMBEs) in Agrypnia Excitata (AE)-Limbic Autoinmune Encephalopathy (AE-LAE).

GARAY A; BLANCO, S.

Los Angeles

Congreso; AAN 70th Annual Meeting; 2018

American Academy of Neurology

?Agrypnia Excitata? (AE) is a term coined originally by Lugaresi and Provini to describe a syndrome caused by a dysfunction in thalamo-limbic circuits inducing severe insomnia, mental confusion, dream enactment, motor and autonomic activation. This syndrome is observed in fatal familial insomnia (FFI), limbic autoinmune encephalopathy (LAE), delirium tremens (DT) and Mulvihill-Smith syndrome1-2. Oscillatory EEG rhythms could be observed in these patients, resembling the named cyclic alternating pattern (CAP) in NoREM sleep in other physiological and pathological situations, but, during REM sleep-wakefulnes oscillatory pattern ("pseudosleep") in patients with FFI3-4. Also, has been described in neurodegenerative disorders and severe obstructive sleep apnea (OSAS) episodes of REM Behavior, arousal-related motor-behavioral episodes (AMBEs) and Status Dissociatus (SD)5-7. Now, we attempt to extend previous findings8 and to characterize the oscillatory behavior observed in our case of proven AE-LAE using mathematical EEG/EKG polysomnographic (PSG) analysis techniques9-10.