CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Retinopathy Of Prematurity In Small-for-gestational-age Premature Infants
Autor/es:
JULIO A. URRETS-ZAVALIA; ERNA G. KNOLL; MARIA E. FORNIES-PAZ; NICOLAS CRIM; PAULA B. LOPEZ-GIORDANO; RODOLFO MONTI; ELIZABETH COLLINO; HORACIO M. SERRA
Reunión:
Congreso; ARVO; 2011
Resumen:
Purpose:
To evaluate the possible association between retinopathy of prematurity
(ROP) and percentiles of birth: according-to-gestational-age (AGA),
small-for-gestational-age (SGA), or large-for-gestational-age (LGA)
premature infants (PI).Methods: 117 PI were evaluated
prospectively in the Neonatology department of a 3rd level public
hospital in Cordoba, Argentina, that were born at or with a referral of
≤24 h to our unit from May 2009 through November 2010, in order to
evaluate ROP prevalence and severity. In each control, body weight and
weight gain were recorded, and both eyes fully dilated and examined with
binocular indirect ophthalmoscopy by experienced ophthalmologists in
ROP screening. First exam was performed between the 2nd and the 4th week
of life.Results: Infants were grouped according to
birth weight (BW): ≤1000g (10 infants-8.5%), 1000-1500g (26-22.2%),
1500-2000g (32-27.3%), 2000-2500g (34-29%), ≥2500g (15-12.8%); according
to gestational age (GA): ≤29 weeks (7 infants-5.9%), 29-32 weeks GA
(33-28.2%) and 33-36 weeks (77-65.8%), and according to their
percentiles they were classified in SGA (45patients-38.5%), AGA
(69-59%), and LGA (3-2.5%). Mean weight gain (WG) was: SGA 19.8±6.2g/day
(r=20.28 to 23.60); AGA 15.84 ± 9.56g/day (r= -10.65 to 41.66) and LGA
3.46 ± 1.09g/day (r=2.50 to 4.65). All types ROP were diagnosed in 11
(9.4%) patients; 10 infants (90.9%) were SGA, 1 (9.1%) AGA and none was
LGA. In 5 infants (45.5%) had type 1 ROP; 4 of those infants (36.5%)
were treated and 1 showed spontaneous involution. The principal related
causes for SGA prematurity were uncontrolled gestation and maternal
malnutrition.Conclusions: The prevalence of ROP was
extremely high in SGA premature infants compared with PI that were in
accordance with GA. Severe ROP was also higher in SGA PI compared with
PI that were in accordance with GA. SGA prematurity should be considered
an important risk factor for ROP blindness, and those infants should be
monitored carefully.