- A NANOSTRUCTURE OF ASCORBYL PALMITATE USED AS VACCINE PLATFORM IMPROVE ANTIGEN-SPECIFIC MEMORY RESPONSE AND RETAINS THE ANTIGEN AT THE INJECTION SITE

DHO, NICOLÁS DANIEL; PALMA, SANTIAGO; MALETTO, BELKYS ANGÉLICA; MARIN, CONSTANZA; ALLEMANDI, DANIEL; MORON, VICTOR GABRIEL; RUIZ MORENO, FEDERICO; PASCUAL, MARÍA MERCEDES; PISTORESI, MARÍA CRISTINA

Congreso virtual

Congreso; Reunión Anual de Sociedades de Biociencias; 2020

Sociedad Argentina de Inmunología

Subunit vaccines are safe and less expensive than conventional vaccines, but they induce a poor immune response for which the use of an adjuvant is required For that, we explored a new vaccine strategy, antigen ovalbumin ( and CpG ODN (adjuvant approved in 2018 by FDA for a human vaccine) were nanoformulated with a liquid crystal bilamellar nanostructure (Coa ASC 16 formed by self assembly of 6 O ascorbyl palmitate Previously, we demonstrated that the nanoformulation elicited immune response superior to those induced by the soluble counterpart Here, we study the effect of different formulation strategies of same vaccine components on the antigen specific memory response and the persistence of the antigen at the injection site