Tissue-specific IL-17-mediated immunity in experimental dermatophytosis

GUASCONI L; THEUMER MG; . CERVI L.; BURSTEIN V; MENA C; PRINZ I; CHIAPELLO, LAURA S.; BECCACECE I; MASIH DT; GRUPPI A

San Salvador de Bahía

Congreso; International Congress of International Society of Human and Animal Mycology (ISHAM) and Infecciones Fúngicas en la Práctica Clínica de Latino América (INFOCUS); 2019

International society of human and animal mycology

Despite the intimate contact we have with dermatophytes, little is known about how our immune system protects us from these pathogens and how pathogenic fungi drive skin immune homeostasis. Most studies that analyse antifungal immunity used generic populations of myeloid cells to better understand the mechanisms of fungal growth control.However, it is clear that our immune system exhibits organ-specific restrictions. This study directly explores the skin-specific antifungal immunity in vivo and monitors the dynamics of cutaneous T cell populations necessary for protection and homeostasis