Thymic maduration and exportation of innate CD8+ T cells to secondary lymphoid organs (SLO),

CONSTANZA SAVID FRONTERA; VIANO, MARIA ESTEFANIA; CERBAN F; BAEZ, NATALIA S.; RODRÍGUEZ GALÁN MC.

Tucumán

Congreso; Reunión de la Sociedad Argentina de Inmunología; 2019

Sociedad Argentina de Inmunología (SAI)

Innate CD8+ T cells are a subset of CD8+ T cells that have been described in mice and human. They mature in the thymus like conventional T cells and can exert a protective effect both in neoplastic and infectious processes.Our previous work demonstrated that during the acute stage of certain infections (Trypanosoma cruzi or Candida albicans), there is an increase in Innate CD8+ T cells in the thymus. This effect is mediated by the inflammatory process since we observe similar data when we induce systemic expression of IL-12 and IL-18 by hydrodynamic injection of their cDNAs.Our recent data demonstrate that Innate CD8+ T cells generated in the thymus of T. cruzi-infected mice, that were intrathymically stained with the dye eFluor660, can be tracked in increasing numbers in SLO from day 3 to day 6 as eFluor660+ cells (p