CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
IL-17a reverts the reduction in CD8+ T cell response generated by anti-CD20 treatment.
Autor/es:
BECCARIA CG; TOSELLO BOARI J; MONTES CL; ALMADA L; FIOCCA VERNENGO F; GOROSITO SERRÁN M; ARAUJO FURLÁN CL; ACOSTA RODRIGUEZ EV; GAZZONI Y; GRUPPI A
Reunión:
Congreso; SAIC-SAI-SAFIS 2018.; 2018
Resumen:
Anti-CD20 therapy, that depletes B cells, is widely usedto treat autoimmunity and lymphomas. B cells can regulateT cell responses because they have antibody independentfunctions, such as antigen presentation andcytokine secretion. To evaluate the effect of anti-CD20treatment on CD8+T cell response we used the experimentalmodel of Trypanosoma cruzi infection, sinceCD8+T cells are essential for infection control.For that, anti-CD20 mAb was injected eight days beforeinfection with 5000 trypomastigotes, to deplete B cellsand CD8+T cell response was analyzed at different dayspost infection (dpi). Infected control mice were injectedwith an isotype antibody.At 20 dpi, B-cell depleted mice (BcD) exhibited higherparasitism (determined by parasite DNA quantificationby RT-PCR) in the spleen, liver and heart than controls(p