CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of Innate CD8+ T cells in cancer
Autor/es:
BAEZ, NATALIA SOLEDAD; SAVID FRONTERA, CONSTANZA; RODRIGUEZ-GALAN, MARIA CECILIA
Lugar:
Mar del Plata
Reunión:
Congreso; REUNION CONJUNTA SAIC SAI SAFIS- LXVI REUNION ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGIA (SAI); 2018
Institución organizadora:
Sociedad Argentina de Inmunologia
Resumen:
Innate CD8+ T cells were discovered about 10 years ago. These cells have particular phenotypic features (CD44hi CD122hi CD49dhi) and exert cytotoxic activity through NKG2D without specific antigen recognition. Innate CD8+ T cells express high levels of the transcription factor Eomesodermin, known to be induced by IL-4, and low expression of T-bet. They rapidly produce IFN after IL-12 and IL-18 stimulation due to constitutive expression of their receptors. Moreover, an antitumor role of innate CD8+ cells has been recently postulated both in mice and human. Our experiments using murine tumor cell lines demonstrate that systemic expression of IL-12+IL-18 (by hydrodynamic injection of its cDNAs) significantly increased the number of innate CD8+ cells in SLO (spleen and lymph nodes) and attenuate tumor growth in OT-I mice compared to control group (injected with an empty cDNA) (p