CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
REGULATION OF KLF6 TRANSCRIPTION FACTOR
Autor/es:
BOCCO J.L.
Lugar:
San Miguel de Tucumán, Argentina
Reunión:
Congreso; XLV Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; 2009
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Resumen:
Krüppel-like factor 6 (KLF6) is a transcription factor identified in our group, belonging to a family of gene regulators that shear a conserved zinc finger DNA-binding domain and are implicated in diverse steps of cell growth and differentiation. Independent studies reported mutations within the klf6 gene in different human neoplasms, suggesting a potential tumor suppressor function for KLF6. We have demonstrated the ability of KLF6 to promote degradation of the c-Jun proto-oncoprotein by the proteasome pathway leading to inhibition of cell proliferation, which is one of the mechanisms contributing to KLF6 tumor suppressor activity. Current experimental evidence suggests that KLF6 function on c- Jun oncoprotein have consequences on apoptotic cell death triggered by UV-radiation. This function is dependent on both JNK and p38 MAP kinases activities. Moreover, a differential KLF6 effect was observed to activate c-Jun phosphorylation by JNK2 in a transient manner which is essential to switch the death programme of otherwise apoptotic-resistant cells due to JNK1 deficiency. Integrity of p38 kinase activity is critical for both KLF6 stability and apoptosis. In conclusion, c-Jun oncoprotein activity can also be modulated by KLF6 in the context of UV-induced cell death in a JNK and p38 dependent pathways. This property can also be exploited by bacterial toxins and during viral infections.