CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Community-acquired outbreak of invasive Streptococcus pyogenes disease among children hospitalized in a Pediatric Hospital in Córdoba, Argentina
Autor/es:
GARNERO A; SOLA C; CARVAJAL L; BERTONI L; CULASSO C; OLMOS ME; BOCCO JL; GLATSTEIN E
Lugar:
Buenos Aires
Reunión:
Congreso; 6th World Congress of the World Society for Pediatric Infectious Diseases- WSPID 2009; 2009
Institución organizadora:
World Society for Pediatric Infectious Diseases
Resumen:
Most of the serious invasive infections-(SII) by Group A Streptococci-(GAS) arise sporadically in the community, but outbreaks of them have been reported in closed environments such as military populations, family communities and hospitals. A community-acquired outbreak involving 6 cases of SII was detected in a pediatric hospital in Córdoba. The aim of this work was to describe the clinical and epidemiological features of this cluster of GAS invasive diseases and to determine the characteristics of these GAS isolates. The clinical and demographic information of 6 patients with GAS invasive disease, which were hospitalized in the period September-November 2008 at “Hospital de Niños de la Santísima Trinidad”, Córdoba, was analyzed retrospectively. GAS isolates were analyzed by pulse-field-gel electrophoresis-(PFGE) and the toxin genes profile. The average age of the six patients was 29.3 months (range 9-60 months), which were immunocompetent and 50% of them had varicella as underlying medical conditions. Four out of six (67%) had necrotizing pneumonia, three of them had complicated pleural effusions and one had also toxic shock syndrome. The two remaining patients had necrotizing fasciitis and one of them developed also toxic shock syndrome, which died. Four of six GAS isolates shared the same genomic pattern by PFGE (A) and two had different pulsotypes. The low incidence of these SII in the community and the description of the six episodes clustered in time and space could justify the existence of an outbreak. This data is supported by additional evidence: 4/6 isolates share the same pulsotype by PFGE. This is the first outbreak of community-acquired invasive infections in Córdoba. The systematic surveillance of SII caused by GAS in this city could provide new insights into this phenomenon.November 2008 at “Hospital de Niños de la Santísima Trinidad”, Córdoba, was analyzed retrospectively. GAS isolates were analyzed by pulse-field-gel electrophoresis-(PFGE) and the toxin genes profile. The average age of the six patients was 29.3 months (range 9-60 months), which were immunocompetent and 50% of them had varicella as underlying medical conditions. Four out of six (67%) had necrotizing pneumonia, three of them had complicated pleural effusions and one had also toxic shock syndrome. The two remaining patients had necrotizing fasciitis and one of them developed also toxic shock syndrome, which died. Four of six GAS isolates shared the same genomic pattern by PFGE (A) and two had different pulsotypes. The low incidence of these SII in the community and the description of the six episodes clustered in time and space could justify the existence of an outbreak. This data is supported by additional evidence: 4/6 isolates share the same pulsotype by PFGE. This is the first outbreak of community-acquired invasive infections in Córdoba. The systematic surveillance of SII caused by GAS in this city could provide new insights into this phenomenon.