Chronic prostate inflammation induced by E. coli infection leads to tissue lesions associated to prostate cancer development

VIRGINIA E RIVERO; FLORENCIA C. SALAZAR; CAROLINA OLIVERA; RUBEN D MOTRICH; GLORIA J GODOY

Buenos Aires

Congreso; Reunión conjunta de Sociedades de biociencias.; 2017

Sociedad Argentina de la Inmunología

Prostate cancer (CaP) is the second most frequent type of cancerin men. Prostate carcinogenesis is multifactorial and severalenvironmental and genetic factors are involved. In this set, chronicinflammation was suggested as an important risk factor by severalepidemiological studies. Herein, and using an animal model, weanalyzed if chronic prostate inflammation caused by Escherichia coliinfection may have a role in prostate carcinogenesis.Male C57BL/6 mice were transurethrally inoculated with 2x108CFU of uropathogenic E. coli 1677 (infected) or saline (controls),euthanized at 5 days (dpi), 12 and 26 weeks (wpi) post infection,and the immune response, prostate infiltrating leukocytes and histopathologyanalyzed.Inoculated animals developed an ascending infection early afterinfection (5 dpi) that persisted along time (12 and 26 wpi). Infectioninduced inflammation that was characterized by significantlyincreased circulating IL17+ and IFNg+ T cells when compared withcontrols (p