LSP1-DEFICIENT MICE HAVE AN IMPAIRED CONTROL OF MELANOMA TUMOR GROWTH.

MORON, VICTOR GABRIEL; PASCUAL, MARÍA MERCEDES; ACLAND STRACK, RACHEL PAOLA; LUQUE, CAROLINA

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Inmunología

Leukocyte-specific protein 1 (LSP1) is a 52kDa cytoplasmic F-actin binding phosphoprotein expressed in all human and murine leukocytes as well as in endothelial cells. LSP1 in known as an important regulator of actin cytoskeleton remodeling. Our group has previously shown that Lsp1-/- mice have an impaired CTL response after antigen exposure, with Lsp1-/- dendritic cells (DCs) failing to induce a strong CTL response in vivo, to migrate to lymphoid tissues and to properly present antigens. To study the role of LSP1 in antitumor immune response, we employed the MO5 melanoma model. WT and Lsp1-/- mice were injected subcutaneously with 105 MO5 cells and followed-up until day 26. Tumors in Lsp1-/- mice grew significantly faster and bigger than in WT mice (p