Changing Epidemiology of MRSA Clones in Argentina: Community Associated MRSA Strains as Main Responsible of Hospital Onset Infections

MRSA ARGENTINA GROUP; ANA L. EGEA; ALEJANDRA CORSO; JOSE LUIS BOCCO; CLAUDIA SARKIS; CELESTE LUCERO; CLAUDIA SOLA; FERNANDO PASTERAN ; P CERIANA

Madrid

Congreso; European Congress of Clinical Microbiology and Infectious Diseases 2018(ECCMID 2018); 2018

European Society of Clinical Microbiology and Infectious Diseases

Background: The emergence of community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA)has transformed the epidemiology of MRSA over the last 15 years. In Argentina, the spread of the CA- ST5-IV andCA-ST30-IV clones in the community and, hospital-associated (HA)-ST5-I in the hospital setting has been reported.We aimed to investigate the molecular epidemiology of MRSA infections in both community and hospital settingin Argentina.Materials/methods: Consecutive S.aureus clinical isolates were collected during May-2015 from 61 hospitals in21 Argentinian provinces and BA city and subjected to antimicrobial susceptibility testing. Healthcare-onset(HO)/community-onset (CO) infections were defined when MRSA was obtained after/before 48 hours ofhospitalization. MRSA strains were genetically typed as CA-MRSA and HA-MRSA by SCCmec, spa-typing, PVL,PFGE and MLST.Results: A total of 668 S.aureus were collected; 471 (70%) were from CO infections and 341 (51%) were MRSA(45.2% CA- and 5.8% HA-).Of all patients, 251 were children (