Deficiency in the IL-17RA/IL-17 pathway affects protective CD8+ T cell immunity in a model of tumor vaccination.

GRUPPI, ADRIANA; BECCARIA, CRISTIAN; TOSELLO BOARI JIMENA; MONTES, CAROLINA L.; BOSSIO, SABRINA N.; ARAUJO FURLAN, CINTIA; ACOSTA RODRÍGUEZ, EVA; BOCCARDO, SANTIAGO; CANALE, FERNANDO P.; RODRÍGUEZ CONSTANZA

Buenos Aires

Congreso; LXV Reunión Anual de la Sociedad Argentina de Inmunología; 2017

Sociedad Argentina de Inmunología

The role of IL-17 cytokines in cancer remains controversial asanti- and pro-tumoral effects have been described. We and othersdemonstrated that IL-17 family plays a central role for the inductionof NK and CD8+ T cell (CTL) responses. As these subsets arecritical for cancer resistance, we evaluated the role of IL-17/IL-17Rin modulating anti-tumor immunity and tumor progression. To thisend, B6 (WT), IL-17RA KO (RKO) and IL-17A/F double KO (DKO)mice were injected with tumor cell lines exhibiting progressor (B16-SIY and MCA101-OVA) and regressor (MC57-SIY) growth patterns.Previously, we showed that volumes of B16 and MC57, but notMCA101, tumors were increased in RKO and DKO mice comparedto WT mice at several days post injection (dpi). Analysis of the primaryimmune response against MC57 demonstrated that compared toWT controls, DKO mice presented reduced numbers of SIY-specificCTL in draining-lymph nodes at d12pi (p