Chagas disease in an obesogenic context: a highlight role for adipose visceral tissue as a chronic reservoir of Trypanosoma cruzi that contributes to associated cardiovascular complications

SANMARCO LM; PONCE N; AOKI MP; EBERHART N; ANDRADA MC; CANO R; CABALÉN MARÌA E; CABRAL MARÍA F; GEA S

Congreso; Reunion Conjunta de Sociedades de Biociencias; 2017

Chagas disease and obesity are chronic and public health concerns with associated cardiovascular complications (CV). Oxidative stress (OS) and inflammation are common mechanisms that pre dispose to CV. We hypothesize that in an obesogenic context, the immune-metabolic dysregulation exerted by T. cruzi infection could drive CV.To elucidate this complex interrelation, we evaluate the lipid and lipoprotein systemic changes and the oxidative and immune-in flammatory alterations in visceral adipose tissue (VAT) in uninfected C57BL/6 mice feed with LFD (4% fat diet) or DIO (14% fat/ 5% fructose diet), or infected (LFD+I and DIO+I) groups. Although an improvement on plasma triglycerides (TG) and total cholesterol (TC) levels were seen in DIO+I compared to DIO mice (p