CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A strong inflammatory and an efficient regulatory response are essential to restrict parasite replication and prevent immunopathology during T. cruzi infection. Despite its ability to control parasite replication, infected B6 mice are unable to expand reg
Autor/es:
AMBROSIO, LF; CERVI, LAP; INSFRAN, CONSTANZA; MOTRAN, CLAUDIA C; VOLPINI, XIMENA
Lugar:
CABA
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
SAIC-SAI
Resumen:
A strong inflammatory and an efficient regulatory response are essentialto restrict parasite replication and prevent immunopathologyduring T. cruzi infection. Despite its ability to control parasite replication,infected B6 mice are unable to expand regulatory T cells(Treg), resulting in the premature death by inflammatory liver failure.In T cells, the ligation of AhR, (a ligand-activated transcription factorthat plays important roles in several biological processes) with thexenobiotic TCDD up-regulates the expression of Foxp3. We havereported that the treatment of B6 mice with TCDD 24 h prior T. cruziinfection is able to control the inflammatory response increasing the% of Treg but also increasing the parasite burden and impairing thesurvival. To determine the effect of TCDD treatment on the modulationof T cell response during the acute infection we treated B6mice with TCDD (40 ug/kg) 24 h before being infected with T. cruziand analyzed the spleen Treg and Th cell populations at day 10 pi.TCDD group showed increased parasite burden and levels of serumAST and ALT associated with impaired survival compared withcontrol group. TCDD group presented markedly reduced spleens(p