MODULATION OF PURINERGIC SIGNALING HAS A TISSUE-DEPENDENT IMPACT ON THE IMMUNE RESPONSE AGAINST TRYPANOSOMA CRUZI INFECTION

NATALIA EBERHARDT; NICOLÁS ERIC PONCE; MONICA CRISTINA GARCIA; MARIA DEL PILAR AOKI; LILIANA MARIA SANMARCO; MARTIN GUSTAVO THEUMER

Buenos Aires

Congreso; I Reunión de Biociencias; 2017

Sociedad Argentina de Inmunología

Adenosine (ADO), an immune-regulatory metabolite, is producedby hydrolysis of ATP that accumulates during tissue injury and inflammation. ADO generated through CD73 activity is an extracellularsignaling molecule that is involved in anti-inflammatory mechanismsand provides a feedback to control tissue damage mediated by thehost immune response to several infections. We hypothesize thatthe balance between ATP and ADO is crucial in the development ofChagas disease. The aim of this study was to determine the balanceof purinergic signals and its impact in the host immune responsedeveloped in different T. cruzi target tissues. The kinetic of cardiacmacrophage (Ma) subsets showed a predominant inflammatory/M1profle throughout the acute infection (p