CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CHAGAS DISEASE IN AN OBESOGENIC CONTEXT: A HIGHLIGHT ROLE FOR VISCERAL ADIPOSE TISSUE AS A CHRONIC RESERVOIR OF Trypanosoma cruzi THAT CONTRIBUTES TO ASSOCIATED CARDIOVASCULAR COMPLICATIONS
Autor/es:
LILIANA MARIA SANMARCO; MARTA ANDRADA; MARIA DEL PILAR AOKI; EUGENIA CABALÉN; MARIA FERNANDA CABRAL; SUSANA GEA; NATALIA EBERHARDT; NICOLÁS ERIC PONCE; ROXANA CAROLINA CANO
Lugar:
Buenos Aires
Reunión:
Congreso; I Reunión de Biociencias; 2017
Institución organizadora:
Sociedad Argentina de Protozoologia
Resumen:
Chagas disease and obesity are chronic and public health concerns with associated cardiovascular complications (CV). Oxidativestress (OS) and inflammation are common mechanisms that predispose to CV. We hypothesize that in an obesogenic context, theimmune-metabolic dysregulation exerted by T. cruzi infection coulddrive CV.To elucidate this complex interrelation, we evaluate the lipid andlipoprotein systemic changes and the oxidative and immune-inflammatory alterations in visceral adipose tissue (VAT) in uninfected C57BL/6 mice feed with LFD (4% fat diet) or DIO (14% fat/ 5%fructose diet), or infected (LFD+I and DIO+I) groups. Although animprovement on plasma triglycerides (TG) and total cholesterol(TC) levels were seen in DIO+I compared to DIO mice (p