Monocytes from chagasic patients are hyperinflammatory: Characterization of hypoxia response pathways in different monocyte subsets

SANMARCO, LILIANA MARIA; PONCE, NICOLÁS E.; MINGUEZ, ÁNGEL R.; EBERHARDT, NATALIA; ELIZONDO, DIEGO F.; VISCONTI, LAURA M.; RAMELLO, MARIA CECILIA; AOKI, MARIA PILAR

Austin, Texas

Congreso; Mononuclear Phagocytes in Health, Immune Defense and Disease (D3); 2017

Monocytes (MO) represent a heterogeneous population of innate immune effector cells. Three different subsets can be distinguished in humans: classical (CD14++CD16-), intermediate (CD14++CD16+), and non-classical MO (CD14+CD16++). Considering that different human inflammatory diseases evidence MO subset perturbations, our aim was to characterize the effect of chronic Chagas disease on the frequency and properties of different circulating MO subpopulations. We observed that seropositive individuals showed a higher frequency of hypoxia inducible factor (HIF)-1α+ and nitric oxide (NO)-producing MO compared to seronegative donors (p