T3 Reinvigorates Dendritic Cells and Potentiate AntiTumor Immunity

PELLIZAS CG

Orlando, FL

Congreso; 99th Annual Meeting from the Endocrine Society; 2017

Endocrine Sociey

Studies on the impact of Thyroid Hormones (THs) at the initiation of adaptive immunity are emerging. We showed that dendritic cells (DCs) express TRs, mainly the 1 isoform, and that physiological levels of triiodotironine (T3) contributes to their maturation and function, through the activation of TR1, Akt and NF-kB pathways.The identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a challenge to improve DC-based cancer vaccines. We provide evidence for a critical role of T3 in controlling the antitumor functions of DCs. By in vitro and in vivo strategies, we reported that TR signaling endowed DCs with the ability to stimulate antigen-specific cytotoxic T-cell responses during tumor development. In a B16 mouse model of melanoma, vaccination with T3-stimulated DCs inhibited tumor growth and prolonged host survival. Our findings highlight the use of T3-conditioned DCs as an alternative approach to potentiate T-cell?mediated tumor immunity.