Role of innate CD8+ T cells in cancer.

RODRIGUEZ-GALAN, MARIA CECILIA; SAVID FRONTERA, CONSTANZA; BAEZ, NATALIA SOLEDAD

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Innate CD8+ T cells were discovered about 10 years ago. Thesecells have particular phenotypic features (CD44hi CD122hi CD49dhi)and exert cytotoxic activity mainly through NKG2D expression with-out specific antigen recognition. Innate CD8+ T cells express highlevels of the transcription factor Eomesodermin and low expressionof T-bet. They rapidly produce IFNg after IL-12 and IL-18 stimulationdue to constitutive expression of their receptors. Moreover, an an-titumor role of innate CD8+ cells has been recently postulated bothin mice and human. Our experiments using murine tumor cell linesdemonstrate that systemic expression of these 2 cytokines (by hy-drodynamic injection of their cDNAs) significantly attenuate tumorgrowth in WT mice compared to control group (injected with an emp-ty cDNA) (p