. ARYL HYDROCARBON RECEPTOR SIGNALING MODULATES CD8 + T CELL EFFECTOR AND MEMORY SUBPOPULATIONS DURING THE INFECTION WITH TRYPANOSOMA CRUZI.

INSFRAN, CONSTANZA; SERRA, HORACIO; VOLPINI, XIMENA; AMBROSIO, LF; MOTRAN, CLAUDIA CRISTINA

Mar del Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC) LXIV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI); 2016

SAIC-SAI

The acquisition of memory T cells is defined by thegeneration and persistence of T cells that can providelong-lasting protection against pathogens. Signals givenby dendritic cells (DC) as TCR engagement, costimulationand cytokines, co-participate in the induction of memory Tcells. Thus, changes in any of the factors controlling theactivation of T cells during antigen presentation by DC canregulate T effector and memory cell differentiation. Differentobservations suggest that AhR, is a ligand-activatedtranscription factor that plays important roles in severalbiological processes, modulates critical events in theactivation of naive T cells that could modify the developmentof effector and memory T cells. To investigate therole of AhR activated by natural ligands generated duringT. cruzi infection, B6 (WT) and B6 mice carrying a mutantAhR protein with reduced affinity for its ligands (AhRd)were infected with 100.000 T. cruzi trypomastigotes anddifferent splenic subpopulations of CD8+ T cells werestudied by FACS at day 10 and 170 postinfection (pi).AhRd mice showed significantly lower frecuency andnumber of CD8+ T cells specific for the inmunodominantepitope TSKB20 (ANYKFTLV) than WT mice at day 10pi, (p