Desarrollo de células T innatas en timo bajo condiciones infecciosas/inflamatorias sistémicas

CERBAN, FABIO; BAEZ, NATALIA SOLEDAD; RODRIGUEZ-GALAN, MARIA CECILIA; SAVID FRONTERA, CONSTANZA

Mar del Plata

Congreso; LXI REUNIÓN CIENTÍFICA ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA Y LXIV REUNIÓN CIENTÍFICA ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA.; 2016

Sociedad Argentina de Inmunología

Our previous work demonstrated that during the acutestage of certain infections (Trypanosoma cruzi or Candidaalbicans) with a strong Th1 component, the number ofCD8+CD44hi T cells in the thymus increased. These cellsare named ?innate T cells? and belong to a differentlineage from conventional SP CD8 thymocytes that giverise in the thymus. They express the transcription factorEOMES, produce high levels of IFNg and differentiatein the presence of IL4 and IL15. This effect is mediatedby the inflammatory process since we obtained similardata when we induced systemic expression of IL12 andIL18 by hydrodynamic injection of their cDNAs. The aimof our work is to determinate the origin and functionof these cells. Our flow cytometry data demonstratedthat these cells express the killing receptor NKG2Dand have high cytotoxic activity measured by CD107aexpression assay (p