IL-6 drives cardiac macrophage profile and regulates the lethal release of Nitric Oxide through IL- 1β inhibition during parasite infection

SANMARCO L.M.; PONCE N.E.; EBERHARDT N.; AOKI M.P.

Buenos Aires

Congreso; LASID 2015; 2015

Monocytes/Macrophages are a heterogeneous population of immune cells that have arange of roles in the induction and resolution of inflammation. The nitric oxide (NO) production isassociated with the killing of microorganisms and characterizes M1-type macrophage response. Thefactors involved in cardiac macrophage profile differentiation during T. cruzi infection have not beencharacterized. The aim of the present work was to study whether myocardial IL-6 production candetermine the influx and phenotype of macrophage subpopulations and influence tissueinjury/regeneration during T. cruzi acute infection. We observed that infected C57BL/6 mice (WT)exhibited higher cardiac M1 (CD11b+F4/80+CD86+CD206-) macrophage number than M2(CD11b+F4/80+CD86-CD206+) (p