INDUCTION OF TH2-MEDIATED ALLERGIC ASTHMA IN A MOUSE STRAIN HIGHLY SUSCEPTIBLE TO DEVELOP TH1 RESPONSES

GLORIA JANET GODOY; LEONARDO RODOLFO SANCHEZ ; LUCIANA GARCIA; CRISTINA MALDONADO; RUBEN DARIO MOTRICH; VIRGINIA ELENA RIVERO

Buenos Aires

Congreso; LXIII ReuniónAnual de SAI, I Meeting LASID-SAI-FAIC, IV Meeting LASID, y II Meeting FAIC. Buenos Aires; 2015

LASIG

NOD mice are highly susceptible to chronic inflammation disorders mostly mediated by Th1 responses. This increased susceptibility has been thought to be related to defects in regulatory T cells (Tregs). Recent findings evidenced that Tregs subsets are heterogeneous and that different Tregs subsets able to specifically regulate Th1, Th2 and Th17 immune responses would exist. In this work, we developed a model of allergic asthma following established immunization protocols with OVA plus aluminum salts in NOD, C57BL/6 and Balb/c mice. We aimed to analyze if regulatory defects observed in NOD mice were general or just restricted to Th1 responses. After immunization, mice from every strain showed clinical signs and symptoms of allergy when challenged intranasally with OVA. Although increased leukocyte counts in broncoalveolar lavage (BAL) were detected in both immunized NOD and Balb/c mice, the highest levels were detected in Balb/c mice (p