Assessment of Ly6C, CD64 and F4/80 in monocyte ?macrophages in different inflammatory scenarios.

MACCIO-MARETTO L, BARRIOS BE, NOVOTNY NUÑEZ I, CORREA SG.

Congreso; 2015-IV LASID Meeting-LXIII Argentinian Society for Immunological Meeting-II French-Argentinean Immunology Meeting. 18th-21st November, Buenos Aires, Argentina.; 2015

SAI

Intestinal macrophages are derived from peripheral blood monocytes that reach the lamina propia (LP) in a CCR2-dependent manner. As they arrive and differentiate, monocytes reduce the expression of Ly6c reciprocally acquiring CD64, MHC-II and F4/80 molecules. This pathway is called ?The monocyte-waterfall?, ocurrs phisiologically for the in-situ macrophage renewal, but also gets interrupted at inflamatory conditions.