The follow up of Vitamin A signals in intestinal immunity.

NOVOTNY NUÑEZ I, BARRIOS BE, MACCIO-MARETTO, CORREA SG.

Buenos Aires

Congreso; 2015-IV LASID Meeting-LXIII Argentinian Society for Immunological Meeting-II French-Argentinean Immunology Meeting. 18th-21st November, Buenos Aires, Argentina.; 2015

SAI

The intestinal microenvironment modulates phenotype and activity of dendritic cells (DCs) and imprints ability to produce retinoic acid, the active metabolite of vitamin A (VA) which is critical to acquire homing receptors and to induce regulatory subsets. We studied here cells isolated from afferent lymphatics (AL) post VA administration to establish how long takes DC to acquire their competence before entering the mesenteric lymph nodes (MLN). C57BL/6 mice were feed balanced diet ad-libitum (control group) or balanced diet ad-libitum supplemented once with 5 mg VA (VA group) and AL were isolated at 3, 8, 16 and 24 post administration. Cellularity increased significantly in the VA group after 8hs (p