CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
DO MAMMALS AND AVIAN SHARE SIMILAR PHYSIOLOGICAL IMMUNE-NEUROENDOCRINE STRATEGIES?
Autor/es:
NAZAR FRANCO NICOLÁS; MARÍN RAÚL HÉCTOR; CORREA SILVIA GRACIELA
Lugar:
Buenos Aires, Argentina
Reunión:
Congreso; IV Reunión de la Sociedad Latinoamericana de Inmunodeficiencias. LXIII Reunión de la Sociedad Argentina de Inmunología. II Reunión Franco-Argentina de Inmunología.; 2015
Resumen:
One of the main outcomes of immune-neuroendocrinology has been the description of immune-neuroendocrine phenotypes (INP) in mammals. The concept implies Subgroups within apopulation regarding different characteristics in the immune-neuroendocrine (INE) interactions. A substantial advantage of different and coexistent INP may be an increased ability to deal as a population with a wide range of challenges demanding plastic responses in the INE interplay. INPs are well represented by the Fischer/Lewis paradigm in rats, and were also reported in humans. Tocharacterize the potential evolutionary scope of INP, INE interactions were also evaluated within two populations of domestic avian species: Coturnix coturnix and Gallus gallus. Two subgroups displaying divergent INE interplays were identified in both species and were similarly represented by approximately 15% of the population. They were characterized by lower- and higher-plasma basal corticosterone levels, opposite innate cytokine profiles (interferon-ï?§ and interleukins), and ergo divergent effector responses (lymphoproliferation and antibody response, leukocyte profiles). The fact that The same phenomenon seems to be a shared strategy between mammals and birds highlights its evolutionary advantage meaning. Whether INPs evolved independently or from a common reptilian ancestor remains still open. Further experimentation with other taxa within the evolutionary scale (reptilian, amphibians or fishes) should help to better understand the selective process. In view of the domestication history of the avian species studied, INP could also represent the physiological and evolutionary compromise between the species needs and the pressures imposed by domestication and selective breeding.