CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Tissue-resident microglia and recruited monocytes: relevance in neuroinflammation after peripheral lipopolysaccharide challenge
Autor/es:
JAVIER PERALTA RAMOS; EMILIA GAVIGLIO; DANIELA ARROYO; CLAUDIO BUSSI; PABLO IRIBARREN
Lugar:
Buenos Aires
Reunión:
Congreso; IV Reunión de la Sociedad Latinoamericana de Inmunodeficiencias (LASID), II Congreso Franco-Argentino de Inmunología (FAIC) y LXIII Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2015
Resumen:
Brain-resident microglia (Mi) and blood-derived monocytes, play essential roles in shaping the immune response in the central nervous system. These cells activate and migrate in response to chemokines produced during active immune responses and may contribute to the progression of neuroinflammation. In this study, we investigated the phenotypic and functional profile of tissue-resident microglia and recruited inflammatory monocytes (InfMo), to understand the contribution of each population in the establishment and development of a neuroinflammatory process induced by systemic TLR4 stimulation. We characterized the molecular and cellular players involved in neuroinflammation induced by lipopolysaccharide (LPS - 1.6 mg/kg) i.p. administration to C57BL/6 mice using flow cytometry combined with ex-vivo functional essays and confocal microscopy. Following stimulation with LPS, we found increased absolute number (p