CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of LRP-1 in Müller Glial Cells: Intracellular Signaling Pathways Involved in the Retinal Neovascularization.
Autor/es:
SÁNCHEZ MC; BARCELONA PF; LUNA JD; ORTIZ SG; JUAREZ PC; RIERA CM; CHIABRANDO GA
Lugar:
Fort Lauderdale, FL, USA
Reunión:
Congreso; ARVO´s 2007 Annual Meeting (The Association for Research in Vision and Ophthalmology).; 2007
Institución organizadora:
The Association for Research in Vision and Ophthalmology
Resumen:
Panretinal photocoagulation (PRP) reduces the incidence of severe visual loss in proliferative diabetic retinopathy (PDR). The aim of the study was to determine the effect of PRP on the activity of matrix metalloproteinase-2 (MMP-2) and MMP-9, and also on the a2-Macroglobulin (a2M) proteolytic state in the vitreous of eyes with PDR. Vitreous samples were obtained from patients undergoing vitrectomy for the treatment of retinal diseases: 17 with PDR and eight with idiopathic macular hole (MH). Qualitative evaluation of the MMP-2 and MMP-9 activation status was performed by gelatin zymography and quantitative assay was carried out for vitreous total protein content and a2M. The proteolytic state of proteolytic state in the vitreous of eyes with PDR. Vitreous samples were obtained from patients undergoing vitrectomy for the treatment of retinal diseases: 17 with PDR and eight with idiopathic macular hole (MH). Qualitative evaluation of the MMP-2 and MMP-9 activation status was performed by gelatin zymography and quantitative assay was carried out for vitreous total protein content and a2M. The proteolytic state of a2-Macroglobulin (a2M) proteolytic state in the vitreous of eyes with PDR. Vitreous samples were obtained from patients undergoing vitrectomy for the treatment of retinal diseases: 17 with PDR and eight with idiopathic macular hole (MH). Qualitative evaluation of the MMP-2 and MMP-9 activation status was performed by gelatin zymography and quantitative assay was carried out for vitreous total protein content and a2M. The proteolytic state ofa2M. The proteolytic state of a2M was evaluated by Western blotting2M was evaluated by Western blotting