CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Autophagy induction by TLR2 ligands regulates leukocyte recruitment in the brain
Autor/es:
DANIELA ARROYO; EMILIA GAVIGLIO; JAVIER PERALTA RAMOS; CLAUDIO BUSSI; PAULA AVALOS; LILIANA CANCELA; PABLO IRIBARREN
Lugar:
Mar del Plata
Reunión:
Congreso; LIX Reunión Científico Anual de la Sociedad Argentina de Investigación Clínica (SAIC) y de la LXII Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2014
Resumen:
Microglial cells (MC) are phagocytes in the central nervous system that become activated in pathological conditions, resulting in microgliosis, manifested by increased cell numbers and inflammation in the affected regions. We previously demonstrated that TLR2 has the potential to induce autophagy in MC. Considering this, in this work we evaluated if autophagy play a role in the regulation of the activation and the recruitment of myeloid cells to the brain. We previously observed that injection of peptidoglycan (PGN; TLR2 ligand) from S. aureus, in mouse brain parenchyma (caudate putamen; CPU), resulted in a significant increase in the number of LC3B positive CD45+ microglia/macrophages cells in the site of injection (p