CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
B CELLS REGULATE THE INFLAMMATORY CD4+ T CELL RESPONSE IN TRYPANOSOMA CRUZI INFECTION
Autor/es:
GOROSITO SERRÁN, MELISA; TOSELLO BOARI, JIMENA; RAMELLO, MARÍA CECILIA; BECCARIA, CRISTIAN GABRIEL; FIOCCA VERNENGO, FACUNDO; BERMEJO, DANIELA ANDREA; AMEZCUA VESELY, MARÍA CAROLINA; MONTES, CAROLINA LUCÍA; ACOSTA RODRÍGUEZ, EVA VIRGINIA; GRUPPI, ADRIANA
Lugar:
Mar del Plata
Reunión:
Congreso; LXII REUNIÓN ANUAL - Sociedad Argentina de Inmunología; 2014
Institución organizadora:
Sociedad Argentina de Inmunología - Sociedad Argentina de Investigación Clínica
Resumen:
B cell-deficient mice (mMT) infected with T. cruzi are able to control parasitemia similar to C57BL/6 wild type (WT) mice but present increased parasitemia by 10 days post-infection (dpi) and accelerated mortality. mMT and WT mice have similar tissue parasite load as determined by RT-PCR, indicating that mortality is not caused by uncontrolled parasitism. To assess possible causes of the increased susceptibility of mMT mice, we analyzed cytokine production and CD4+T cell responses in mMT and WT mice infected i.p. with 10000 trypomastigotes Y-br strain. Groups of 4-7 mice were sacrificed by 4, 9, 15, 20 dpi and sera and splenocytes were obtained. By 9 dpi, amounts of serum IFNg were increased in both infected mice strains, but were higher in mMT mice (p