CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ENVIRONMENTAL PROTEINACEOUS CORNEAL DEGENERATION: PREVALENCE IN DIFFERENT REGIONS OF ARGENTINA
Autor/es:
CORREA L; MARIA F. SUAREZ; RODOLFO MONTI; EVANGELINA ESPÓSITO; GONZALEZ MARIA EUGENIA; A. URRETS-ZAVALÍA, JULIO; HORACIO M. SERRA
Reunión:
Congreso; ARVO2014; 2014
Resumen:
Purpose: environmental
proteinaceous corneal degeneration (EPCD) is an acquired degenerative
and potentially handicapping human corneal disease. The aim of this study was to assess the prevalence
of EPCD in 4 different regions of Argentina.
Materials and Methods: a population-based
cross-sectional study was conducted involving individuals living in Santa Catalina (Region 1, n=152); Quebrachos (Region 2, n=154), El Cuy (Region 3,
n=102) and General Roca (Region 4, n=113) departments, who read the summary of the project and signed informed consent. All participants received a complete eye examination and were inquired
about work activity, feeding and use of eye protection. Levels of ascorbic acid
(AA) in individuals? serum, the density of ozone (O3) and values of
UVB levels were studied. Student t-test, ANOVA and Pearson tests were used to
compare values. The statistical significance was set at p<0.05.
Results: individuals with EPCD were only
found in region 3 (20%prevalence). The eating habits were similar in all
studied regions, but for region 4. The primary activity was cattle breeding
excepting for region 4, which was predominantly fruit production. No eye
protection was worn in region 3, where the prevalence of the disease is 20%.
Low serum AA levels were found in individuals from regions 1 and 3 (0.27 mg/dl
± 0.133 and 0.21 mg/dl ± 0.091, respectively) associated with a low fruit and
vegetable consumption (p <0.0001) than those found in region 4 (0.719 mg/dl
± 0.446) where the consumption of fruits and vegetables was higher. All O3
values obtained were within the normal range. The UVB values were inversely
correlated with the levels of O3 (r = -0.87), and the lowest levels
were found in region 3.
Conclusion: a high prevalence of EPCD was
found in region 3 where most of the studied individuals spent several hours
working outdoor with any eye protection. Despite being exposed to normal levels
of UVB these individuals had a partial deficiency of AA that can explain this
higher prevalence. Moreover, EPCD was not found in regions 1 and 2, which have
similar environmental characteristics to region 3, excepting for the habit of
wearing eye protection while working outdoors. There were no cases of EPCD in
region 4 where individuals had a balanced diet without AA deficiency and they
wore eye protection.