IL-17RA REGULATES THE MAGNITUDE OF CD8+ T CELL RESPONSE TO T. CRUZI BY MODULATING APOPTOSIS, CELL EXHAUSTION AND MEMORY DIFFERENTIATION

TOSELLO BOARI J; FIOCCA VERNENGO F; RAMELLO MC; AMEZCUA VESELY C; ARAUJO FURLLÁN C; GOROSITO M; MONTES CL; GRUPPI A; ACOSTA RODRIGUEZ EV

Los Cocos

Congreso; LXI Reunión Anual de la Sociedad Argentina de Inmunología; 2013

Sociedad Argentina de Inmunología

(112) IL-17RA REGULATES THE MAGNITUDE OF CD8+ T CELL RESPONSE TO T. CRUZI BY MODULATING APOPTOSIS, CELL EXHAUSTION AND MEMORY DIFFERENTIATION Tosello Boari, Jimena ; Fiocca Vernengo, Facundo ; Ramello, María Cecilia ; Amezcua Vesely, María Carolina; Araujo Furlán, Cintia ; Gorosito Serrán, Melisa ; Montes, Carolina; Gruppi, Adriana ; Acosta Rodríguez, Eva ; Facultad de Ciencias Químicas-UNC- CIBICI CONICET IL-17RA-signaling promotes host survival during T. cruzi infection by controlling exacerbated inflammation, but additional protective mechanisms would be involved. As development of robust CD8+ T cell (CTL) immunity is a key element for host resistance to T. cruzi, we aimed at evaluating if IL17RA is involved in the generation of protective CTL responses. To address this, we evaluated the magnitude and quality of the CTL response in infected IL17RA knockout (INF-KO) mice in comparison to WT controls. INF-KO mice showed increased tissue parasitism in spleen and liver that correlated with reduced numbers of CTL specific for the inmunodominant T. cruzi epitope TSKB20 (TSKB20- specific CTL, spleen, d20pi: 1,7±1,4x106 in KO vs 5,5±2,3x106 in WT mice, p