CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
B cell-deficient mice infected with Trypanosoma cruzi develop a pro-inflammatory T cell response potentially harmful for the host
Autor/es:
MELISA GOROSITO SERRAN; JIMENA TOSELLO BOARI; DANIELA BERMEJO; CECILIA RAMELLO; FACUNDO FIOCCA-VERNENGO; CAROLINA MONTES; EVA V ACOSTA-RODRIGUEZ; ADRIANA GRUPPI
Lugar:
Puerto Varas
Reunión:
Congreso; XXVII Annual Meeting; 2013
Institución organizadora:
Chilean Society for Cell Biology
Resumen:
Introduction: B cell-deficient mice (C129.BL6mMT) infected with T.cruzi by i.p. injection of 10000 trypomastigotes Y-br strain, present more parasitemia than C57BL/6 wild type (WT) mice and accelerated mortality. To assess possible causes of this increased susceptibility, we studied cytokine production and CD4+T-cell response in infected mMT and WT mice. Material and Methods: Serum cytokines were determined by ELISA. Splenic T-cell populations, and their cytokine production, were studied by flow-cytometry. Results: Both infected mice strains presented by day 9 post-infection (pi) increased serum IFNg, being higher in mMT mice (p