Interferon-gamma. Gene and protein structure, transcription regulation and actions.

GAMERO AM, HODGE DL, REYNOLDS DM, RODRIGUEZ-GALÁN MC, MOHAMADZADEH M AND YOUNG HA. (TODOS LOS AUTORES CONTRIBUYERON DE IGUAL MANERA)

The interferons Characterization and Application.

WILEY-VCH Verlag GMBH & Co. Weinheim. USA.

Lugar: Irvine-USA; Año: 2006; p. 85 - 111

As discussed in this chapter, IFN-g has multiple biological features that demonstrate its importance in host innate and adaptive immune responses. The expression of IFN-g can a.ect all host cells and as prolonged expression is deleterious, mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. its importance in host innate and adaptive immune responses. The expression of IFN-g can a.ect all host cells and as prolonged expression is deleterious, mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. g has multiple biological features that demonstrate its importance in host innate and adaptive immune responses. The expression of IFN-g can a.ect all host cells and as prolonged expression is deleterious, mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. g can a.ect all host cells and as prolonged expression is deleterious, mechanisms are in place for the transcriptional and post-transcriptional regulation of this gene. The width breath of IFN-g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. g biological activity is perhaps best highlighted by the fact that IFN-g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. g gene expression can be induced in NK and T cells by many diverse signals, and this induction is controlled by regulatory elements that have been highly conserved through evolution. The fact that Mother Nature has seen .t to conserve the nucleic acid regulatory elements that control its expression more strongly than the primary amino acid sequence suggest that maintenance of the regulation of IFN-g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. g gene expression is essential to the development of host immunity to prevent cancer and infectious disease. Thus, IFN-g has evolved to represent a critical element in uniting the innate and adaptive immune response. a critical element in uniting the innate and adaptive immune response. g has evolved to represent a critical element in uniting the innate and adaptive immune response.